May 19, 2021

Automation Engineer

  • Freenome
  • South San Francisco, CA

Job Description

Freenome is seeking an Automation Engineer You will play a key role in shaping a culture of efficiency within the clinical laboratory and broader operation. You will take point in optimizing wet, dry, and supporting system integration processes to allow Freenome to prepare for multiple stages of scale-up in an elegant fashion. You will use lab automation and principled design considerations to come up with effective processes based around molecular biology requirements. You will be directly responsible for the implementation of robust processes on robotic systems, and collaborate cross-functionally across the company, including supply chain, regulatory, technology transfer, software engineering, wet R&D. As a valued member of the Automation team, you will also contribute to growing process engineering and laboratory automation expertise within the larger Automation Group, including robotics, process engineering, support, and service. Additionally, you will provide instrument training to clinical lab, support service of instrumentation, and perform just-in-time troubleshooting. About You You have a strong work ethic, know the value of your contribution, and want to make an outsized impact by helping the development and mass-marketing of a life-changing test on the operational side. The laboratory touches multiple fields: enzymatics, manufacturing, software, IT. You're well versed in these areas and can participate significantly in all parts of the operation. The challenges of a startup are exciting and you realize the world-changing value of circulating tumor DNA screening. Freenome is changing the world through a product that has the potential to better the standard of care for all current, future, and potential cancer patients. Our ability to build and maintain scalable and efficient workflows in a clinical environment to deliver an always better product will be the main driver for adoption and you will be a key stakeholder in the success. The automation team is a service provider to the laboratory teams, and the balance between bringing new ideas and processes to the table with managing existing ones and gathering ideas/requirements from the end-users will be a critical part of the success of the automation team. How you’ll contribute: Participate in the design and implementation of efficient workflows, from receiving of labware and reagents to the generation of reports, in support of a rapidly growing clinical organization Design and execute optimization experiments for the execution of molecular biology processes on robotic platforms Continuously assess the state of the operations and prioritize improvements based on expected improvements Provide systematic approaches to implement automation solutions to ensure process scalability, sustainability and reliability Integrate or build innovative laboratory automation tools, instruments, and technologies Design the development of new, automated, and efficient lab processes, with the end goal of processing the world’s volume of genetics tests hands-free Bring a can-do attitude to solve new and challenging problems in a high pace environment What you’ll bring: 4+ years developing and implementing high-efficiency automated workflows Solid technical understanding of lab automation tools used and operation concepts in NGS assay for DNA, and/or RNA, including nucleic acid extraction methods, DNA library preparation workflows, and/or proteomics methods. Proven track record in developing and maintaining robust and efficient automated workflows and successful transfer of technologies and workflows into a high-throughput operation Experience scripting methods on OEM robotic systems with a strong preference for Hamilton and Agilent Bravo Liquid Handlers, or experience scripting on multiple OEM robotic systems more broadly (Tecan, Beckman, etc) Experience in automation-LIMS integration, designing and executing instrument testing/validation plan Functional knowledge in experimental design, bench execution, process optimization, data analysis, and system integration Proven organizational sense to develop an efficient and integrated service, automation and process engineering groups Experience working with a broad set of instruments Solid understanding of lab automation industry and tools available Working knowledge of molecular biology and NGS sequencing Experience working in a regulated environment (CLIA / CAP / NYS / FDA / GCLP) Experience in reagent manufacturing, ideally in a regulated environment (cGMP)

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